Generalized linear mixed models for mapping multiple quantitative trait loci
نویسندگان
چکیده
منابع مشابه
Hierarchical generalized linear models for multiple quantitative trait locus mapping.
We develop hierarchical generalized linear models and computationally efficient algorithms for genomewide analysis of quantitative trait loci (QTL) for various types of phenotypes in experimental crosses. The proposed models can fit a large number of effects, including covariates, main effects of numerous loci, and gene-gene (epistasis) and gene-environment (G x E) interactions. The key to the ...
متن کاملMixture generalized linear models for multiple interval mapping of quantitative trait Loci in experimental crosses.
SUMMARY Quantitative trait loci mapping in experimental organisms is of great scientific and economic importance. There has been a rapid advancement in statistical methods for quantitative trait loci mapping. Various methods for normally distributed traits have been well established. Some of them have also been adapted for other types of traits such as binary, count, and categorical traits. In ...
متن کاملMultiple interval mapping for quantitative trait loci.
A new statistical method for mapping quantitative trait loci (QTL), called multiple interval mapping (MIM), is presented. It uses multiple marker intervals simultaneously to fit multiple putative QTL directly in the model for mapping QTL. The MIM model is based on Cockerham's model for interpreting genetic parameters and the method of maximum likelihood for estimating genetic parameters. With t...
متن کاملMultiple trait analysis of genetic mapping for quantitative trait loci.
We present in this paper models and statistical methods for performing multiple trait analysis on mapping quantitative trait loci (QTL) based on the composite interval mapping method. By taking into account the correlated structure of multiple traits, this joint analysis has several advantages, compared with separate analyses, for mapping QTL, including the expected improvement on the statistic...
متن کاملInterval mapping of multiple quantitative trait loci.
The interval mapping method is widely used for the mapping of quantitative trait loci (QTLs) in segregating generations derived from crosses between inbred lines. The efficiency of detecting and the accuracy of mapping multiple QTLs by using genetic markers are much increased by employing multiple QTL models instead of the single QTL models (and no QTL models) used in interval mapping. However,...
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ژورنال
عنوان ژورنال: Heredity
سال: 2012
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.2012.10